Research

Dr Gaffney has considerable experience in clinical research, having published over 100 original papers and abstracts. Specific interests include Ankylosing Spondylitis, Rheumatoid Arthritis and Osteoporosis. Dr Gaffney leads a research team in Ankylosing Spondylitis and is a regular invited speaker at National and International meetings. Click here for Dr Gaffney’s publications in the Oxford Journals or Google Scholar. Examples of recent publications include:

Original Articles

Tumour Necrosis Factor inhibitor survival and predictors of response in axial spondyloarthritis – findings from a United Kingdom cohort. Yaha F, Gaffney K, Hamilton L, Lonsdale E, Leeder J, Brooksby A, Cavill C, Berry-Jenkins J, Boyle C, Bond D, Sengupta R. Rheumatology 2017; Submitted

Maintenance of low disease activity following dose-tapering TNF inhibitor dose tapering in Ankylosing Spondylitis. Steel L, Yates M, Hamilton L, Gaffney K. J Rheumatology 2017; In press

The prevalence of axial spondyloarthritis in patients with acute anterior uveitis – a cross-sectional cohort study with MRI verification. Sykes M, Hamilton L, Jones C, Gaffney K. Ann Rheum Dis 2016. Submitted

BSR and BHPR guideline for the treatment of axial spondyloarthritis (including ankylosing spondylitis) with biologics. Hamilton L, Barkham N, Bhalla A, Brittain R, Jones G, Mackay K, Marshall D, Marzo-Ortega H, Murphy D, Riddell C, Sengupta R, Siebert S, Van Rossen L, Gaffney K. Rheumatology 2017; 56:313-6.

Comment on “Delay to Diagnosis in Axial SpA: Are We Improving in the UK?”
Sykes M, Doll H, Sengupta R, Gaffney K. Rheumatology (Oxford) 2016; 55: 1707-8
Poor awareness of inflammatory back pain and axial spondyloarthritis amongst secondary care specialists. Mathieson HR, Merashli M, Gaffney K, Marzo-Ortega H. Clin Rheumatol. 2016 Oct; 35(10):2627-8.

Does the co-existence of acute anterior uveitis and chronic back pain prompt primary care physicians to consider a diagnosis of axial spondyloarthritis? Maxwell A, Yates M, Everden P, Gaffney K. Ann Rheum Dis 2016 Apr;75(4):e18. doi: 10.1136/annrheumdis-2015-208983. Epub 2016 Jan 20

The prevalence of axial spondyloarthritis in the UK: a cross-sectional cohort study. Hamilton L, Macgregor A, Toms A, Warmington V, Pinch E, Gaffney K. BMC Musculoskeletal Disorders (2015) 16:392-6.

Delay to Diagnosis in Axial SpA: Are We Improving in the UK?
Sykes M, Doll H, Sengupta R, Gaffney K. Rheumatology (Oxford). 2015; 54(12):2283-4

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1. Cortes A, Pulit SL, Leo PJ, Pointon JJ, Robinson PC, Weisman MH, Ward M, Gensler LS, Zhou X, Garchon HJ, Chiocchia G, Nossent J, Lie BA, Førre Ø, Tuomilehto J, Laiho K, Bradbury LA, Elewaut D, Burgos-Vargas R, Stebbings S, Appleton L, Farrah C, Lau J, Haroon N, Mulero J, Blanco FJ, Gonzalez-Gay MA, Lopez-Larrea C, Bowness P, Gaffney K, Gaston H, Gladman DD, Rahman P, Maksymowych WP, Crusius JB, van der Horst-Bruinsma IE, Valle-Oñate R, Romero-Sánchez C, Hansen IM, Pimentel-Santos FM, Inman RD, Martin J, Breban M, Wordsworth BP, Reveille JD, Evans DM, de Bakker PI, Brown MA. Nat Commun 2015 May 21;6:7146. DOI: 10.1038/ncomms8146

Correlation between clinical and MRI disease activity scores in axial spondyloarthritis. MacKay J, Aboelmagd S, Gaffney K. Clin Rheumatol 2015 Sep;34(9):1633-8

An open label, pilot, multi-centre, step-down, randomised controlled-trial to examine whether etanercept 25mg once weekly is effective in maintaining a clinical response in patients with ankylosing spondylitis who have responded to 50mg once weekly – The ANSWERS trial. Yates M, Elender F, Hamilton L, Dean L, Doll H, Thomas J, Gaffney K. J Rheum 2015 Jul;42(7):1177-85

Comment on: ‘Diagnostic delay in patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis: results from the Danish nationwide DANBIO registry’ by Sorensen et al. Sykes M, Doll H, Gaffney K. Ann Rheum Dis 2014:1. doi:10.1136/annrheumdis-2014-205589

Prevalence of Inflammatory Back Pain in a UK Primary Care Population. Hamilton LE, MacGregor AJ, Warmington V, Pinch E, Gaffney K. Rheumatology 2014; 53: 161-164

Validation of a patient self-reported screening questionnaire for axial spondyloarthropathy in a UK population. Hamilton L, Newman D, Belkhiri A, Toms A, MacGregor A, Gaffney K. Spine (Phila Pa 1976) 2013 ;38(6):502-6

Influences of Inflammatory Polyarthritis on Quantitative Heel Ultrasound Measurements. SR Pye, T Marshall, K Gaffney, R Luben, KT Khaw, AJ Silman, DPM Symmons, TW O’Neill. BMC Musculoskeletal Disorders 2012; 13:133

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility Evans DM, Spencer CC, Gaffney K et al. Erratum in: Nat Genet. 2011 Sep; 43(9):919.

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide
handling in the mechanism for HLA-B27 in disease susceptibility. Evans DM, Spencer CC, Pointon JJ, Su Z, Harvey D, Kochan G, Oppermann U, Dilthey A, Pirinen M, Stone MA, Appleton L, Moutsianas L, Leslie S, Wordsworth T, Kenna TJ, Karaderi T, Thomas GP, Ward MM, Weisman MH, Farrar C, Bradbury LA, Danoy P, Inman RD, Maksymowych W, Gladman D, Rahman P;

Spondyloarthritis Research Consortium of Canada (SPARCC)., Morgan A, Marzo-Ortega H, Bowness P, Gaffney K, Gaston JS, Smith M, Bruges-Armas J, Couto AR, Sorrentino R, Paladini F, Ferreira MA, Xu H, Liu Y, Jiang L, Lopez-Larrea C, Díaz-Peña R, López-Vázquez A, Zayats T, Band G, Bellenguez C, Blackburn H, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Corvin A, Craddock N, Deloukas P, Dronov S, Duncanson A, Edkins S, Freeman C, Gillman M, Gray E, Gwilliam R, Hammond N, Hunt SE, Jankowski J, Jayakumar A, Langford C, Liddle J, Markus HS, Mathew CG, McCann OT, McCarthy MI, Palmer CN, Peltonen L, Plomin R, Potter SC, Rautanen A, Ravindrarajah R, Ricketts M, Samani N, Sawcer SJ, Strange A, Trembath RC, Viswanathan AC, Waller M, Weston P, Whittaker P, Widaa S, Wood NW, McVean G, Reveille JD, Wordsworth BP, Brown MA, Donnelly P. Australo-Anglo-American Spondyloarthritis Consortium (TASC).; Wellcome Trust Case Control Consortium 2 (WTCCC2). Nat Genet. 2011 Jul 10;43(8):761-7.

Services for people with ankylosing spondylitis in the UK. Hamilton L, Gilbert A, Skerrett J, Dickinson S, Gaffney K. Rheumatology 2011; 50: 1991-8.

Factors influencing recruitment to rheumatology. Watson P, Gaffney K. Rheumatology 2011; Clinical Medicine 2011; 11: 509-510.

Influence of arthritis and non-arthritis-related factors on areal bone mineral density (BMDa) in women with longstanding inflammatory polyarthritis: a primary care-based inception cohort. Pye SR, Marshall T, Gaffney K, Silman AJ, Symmons DP, O’Neill TW. BMC Musculoskelet Disord. 2010 May 28; 11:106.

Comment on: Screening for MTB prior to anti-TNF therapy – an audit of impact of the BTS guidelines on rheumatology practice. JD Pradeep, GPR Clunie, K Gaffney, A Brooksby, NJ Innes, P Bradley, A Gulati. Rheumatology 2009; 48: 1332.

Screening for MTB prior to anti-TNF therapy – an audit of impact of the BTS guidelines on rheumatology practice. JD Pradeep, GPR Clunie, K Gaffney, A Brooksby, NJ Innes, P Bradley, A Gulati. Rheumatology 2009; 48: 195.

Switching anti-TNF therapy in ankylosing spondylitis. DJ Pradeep, AC Keat, K Gaffney, A Brooksby, J Leeder, C Harris. Rheumatology 2008; 47: 1726-7.

Recognition of Inflammatory Back Pain and Ankylosing Spondylitis in Primary Care. Jois RN, Gaffney K. Rheumatology 2008: 47; 1364-6.

The influence of biological therapy on return to work in people with work disability due to ankylosing spondylitis. AC Keat, K Gaffney, AK Gilbert, C Harris, J Leeder. Rheumatology 2008; 47: 481-3.

Physical therapy in anti-TNF treated-patients with ankylosing spondylitis. SG Dubey, J Leeder, K Gaffney. Rheumatology 2008; 47: 1100-1.

Rituximab therapy in patients with resistant rheumatoid arthritis: real life experience.
RN Jois, A Masding, M Somerville, K Gaffney, DGI Scott. Rheumatology 2007;46: 980-2

Demographic and Environmental Factors in a Wegener’s Granulomatosis Cluster. J Lee, T Attygalle, K Gaffney, DGI Scott. Ann Rheum Dis 2007; 66: 278-9.

Patient Satisfaction With Rheumatology Practitioner Clinics: Can We Achieve Concordance by Meeting Patients’ Information Needs and Encouraging Participatory Decision Making? AYN Lim, C Ellis, A Brooksby, K Gaffney. Ann Acd Med (Singapore) 2007; 36(2): 110-4.

Low dose infliximab treatment for ankylosing spondylitis: clinically and cost effective. RN Jois, J Leeder, A Gibb, K Gaffney, A MacGregor, M Somerville, DGI Scott. Rheumatology 2006;45: 1566-9.

Prevalence and associated factors for falls in women with established inflammatory polyarthritis. Anna E Oswald, Stephen R Pye, Terence W O’Neill, Diane Bunn, Karl Gaffney, Tarnya Marshall, Alan J Silman, Deborah PM Symmons. J Rheumatol 2006; 33(4): 690-4.

Methotrexate-related pancytopenia.: serious and under-reported? Our experience of 25 cases in 5 years: reply. A. Lim, K Gaffney, DGI Scott. Rheumatology 2006; 45: 363-4

Methotrexate-related pancytopenia.: serious and under-reported? Our experience of 25
cases in 5 years. A. Lim, K Gaffney, DGI Scott. Rheumatology 2005; 44: 1051-55

BSR Guidelines for Prescribing TNF Blockers in Adults with Ankylosing Spondylitis. Report of a working party of the British Society for Rheumatology. A Keat, N Barkham, A Bhalla, K Gaffney, H Marzo-Ortega, S Paul, F Rogers, M Somerville, R Sturrock, P Wordsworth. Rheumatology 2005; 44: 939-47.

Benchmarking – the five-year outcome of rheumatoid arthritis assessed using a pain score, the health assessment questionnaire and the short form 36 (SF 36) in a community-based sample. N Wiles, DGI Scott, EM Barrett, P Merry, E Arie, K Gaffney, AJ Silman, DPM Symmons. Ann Rheum Dis 2001; 60: 956-61.

CD11b-positive blood lymphocytes correlate with disease activity in patients with rheumatoid arthritis. MG Macey, DA McCarthy, K. Gaffney, JD Perry, KA Brown, AC Newland. Clin Exp Rheumatol 1998; 16: 108-9.

Quantitative assessment of the rheumatoid synovial microvascular bed by gadolinium-DTPA- enhanced magnetic resonance imaging. K Gaffney, J Cookson, S Blades, A Coumbe, DR Blake. Ann Rheum Dis 1998; 57: 152-7.

Intra-articular pressure profile of the knee joint in a spectrum of inflammatory arthropathies. S Jawed, K Gaffney, DR Blake. Ann Rheum Dis 1997; 56: 686-9.

Xanthine Oxidase: four roles for the enzyme in rheumatoid pathology. Blake DR, Stevens CR, Sahinoglu T, Ellis G, Gaffney K, Edmonds S, Benbouetra M, Harrison R, Jawed S, Kanczler, Millar TM, Winyard PG, Zhand Z. Biochem Soc Trans 1997; 25(3): 812-6.

A modified form of low-density lipoprotein with increased electronegative charge is present in rheumatoid arthritis synovial fluid. L Dai, Z Zhang, PG Winyard, K Gaffney, H Jones, DR Blake, CJ Morris. Free Radic Biol Med 1997; 22: 705-10.

Activation of the transcription factor NF-kB in human-inflamed synovial tissue. R Marok, PG Winyard, A Coumbe, ML Kus, K Gaffney, S Blades, PI Mapp, CJ Morris, DR Blake, C Kaltschmidt, PA Baeuerle. Arthritis Rheum 1996; 39: 583-91.

Quantification of rheumatoid synovitis by magnetic resonance imaging. K Gaffney, J Cookson, DR Blake, A Coumbe, S Blades. Arthritis Rheum 1995; 38: 1610-17

Intra-articular pressure changes in rheumatoid and normal peripheral joints. K Gaffney, RB Williams, V Jolliffe, DR Blake. Ann Rheum Dis 1995; 54: 670-673.

Intra-articular triamcinolone hexacetonide in knee osteoarthritis: Factors influencing the clinical response. K Gaffney, J Ledingham, JD Perry. Ann Rheum Dis 1995; 54: 379-381.

Detection and investigation of the molecular nature of low-molecular-mass copper ions in isolated rheumatoid knee-joint synovial fluid. D Naughton, J Knappitt, K Fairburn, K Gaffney, DR Blake, Grootveld M. FEBS Letters 1995; 361: 167-172.

Mucocutaneous criteria for the diagnosis of Behcet’s disease: an analysis of clinicopathological data from multiple international centers. JL Jorizzo, JL Abernethy, WL White, HC Mangelsdorf, CC Zouboulis, R Sarica, K Gaffney, C Mat, H Yazici, et al. J Am Acad Derm 1995, 32: 968-976.

Elevated lipoprotein (A) in carotid-artery atherosclerosis is unrelated to restenosis after endartrectomy. J Stinson, G D’Arcy, T Cooke, MP Colgan, M Hall, J Tyrell, K Gaffney, M Grouden, DJ Moore, G Shanik, J Feely. J Vasc Surg 1995; 29: 23-27.

Neutrophil Collagenase in sputum from patients with cystic fibrosis. C Power, CM O’Connor, D McFarlane, S O’Mahony, K Gaffney, J Hayes, MX FitzGerald. Am J Resp Crit Care Med 1994; 150: 818-822.

a1-Proteinase Inhibitor, Elastase activity and lung disease severity in cystic fibrosis. CM O’Connor, K Gaffney, J Keane, A Southey, N Byrne, S O’Mahony, MX Fitzgerald. Am Rev Resp Dis 1993; 148: 1665-70.

The Impact of HIV Disease on an Irish Prison Population. M Murphy, K Gaffney, O Carey, E Dooley, FM Mulcahy. Int J of STD and AIDS 1992; 3: 426-429.

Phlebotomy practice/needle stick injuries/hepatitis B status among interns in a Dublin hospital. K Gaffney, M Murphy, F Mulcahy. Ir Med J 1992; 85: 102-104.

Editorials

The Clinical utility of HLA B27 in axial spondyloarthritis. Lim E, Sengupta R, Gaffney K. Rheumatology 2017: In press.

Should axial spondyloarthritis without radiographic change be treated with anti-TNF agents? Keat A, Bennett AN, Gaffney K, Marzo-Ortega H, Sengupta H, Siebert S, Everiss T. Rheumatology Int 2017; 37:327-36.

Should axial spondyloarthritis without radiographic change be treated with anti-TNF agents? Keat A, Bennett AN, Gaffney K, Marzo-Ortega H, Sengupta H, Siebert S, Everiss T. Rheumatology Int 2017; DOI 10.1007/s00296-016-3635-8. [Epub ahead of print] Review.
PMID: 28035438

Do low-dose anti-TNF regimens have a role in patients with Ankylosing Spondylitis. Yates M, Keat A, Gaffney K. Rheumatology 2016; 55: 769-72.

Expanding the spectrum of inflammatory spinal disease. AS it was, as it is now. Isdale A, Keat A, Barkham N, Bennett A, Gaffney K, Marzo-Ortega H, Sengupta R. Rheumatology 2013;52:2103-5.

Improving the Treatment of Ankylosing Spondylitis in the UK. Keat A, Gaffney K, Cornell T, MacKay K, Marzo-Ortega H, Skerrett J, Van-Rossen L, Wordsworth P. Rheumatology 2011; 50: 1936-9.

Predicting Outcomes in Ankylosing Spondylitis. J. Pradeep, A. Keat, K. Gaffney. Rheumatology 2008; 47: 942-5.

Anti-tumour necrosis factor therapy for ankylosing spondylitis – unresolved issues. R Jois, K Gaffney, A. Keat. Rheumatology 2007; 46: 899-901.

Early Rheumatoid Arthritis – the changing senario. RN Jois, K Gaffney. J Rheumatology Occupational Therapy 2007; 21: 6-8.

Early Rheumatoid Arthritis: approach to management. S Dubey, K Gaffney. Clinical Medicine 2005; 5: 211-3.

Azathioprine and Cyclophosphamide in the management of rheumatoid arthritis. K Gaffney, DGI Scott. Br J Rheumatol 1998; 37: 824-36.

The influence of intra-articular pressure changes on inflammatory arthritis. K. Gaffney, DR Blake. Rheumatology in Europe 1997; 26: 112-3.

Pressure and vascular changes in mobile joints: Implications for inflammatory joint disease. K Gaffney, SE Edmonds, CR Stevens, DR Blake. Scand J Rheumatol 1995; 23: 17-22.

Hypoxia and the rheumatoid joint: Immunological and therapeutic implications. SE Edmonds, G Ellis, K Gaffney, J Archer, DR Blake. Scand J Rheumatol 1995; 23: 151-156.

Case Reports

Sustained remission of type I diabetes following rituximab therapy. Robinson A, Gaffney K. Rheumatology 2016: Submitted

Large vessel vasculitis ; a rare but preventable cause of stroke. H Pathak, CY Yong, K Gaffney. Indian J Rheumatol March 17, 2017, IP: 64.233.173.12

Delayed presentation of Wegener’s granulomatosis with pancreatic involvement. L. Hamilton, K. Gaffney, Andreou A, Saada J. International Journal of Rheumatic Diseases 2011; 14: 54-55.

An unusual case of chest pain. N Hassan, K Gaffney. BMJ 2008; 337: a898

Like father, like son. J Lee, P Merry, Ball R, K. Gaffney. Ann Rheum Dis 2007; 66: 1686-7

Spontaneous remission in Wegner’s Granulomatosis. J Thomas, K Gaffney. Scand J Rheumatol 2007; 36: 324-6.

Methotrexate associated lymphoproliferative disorder masquerading as interstitial lung disease. R Jois, K Gaffney, P Cane, A Nicholson, A Wotherspoon. Histopathology 2007; 51:709-12

Juvenile onset spondylodiscitis – magnetic resonance imaging changes with Infliximab. A Lim, K Gaffney, T Marshall. Rheumatology 2004; 43:1456-8

Chronic Periaortitis, Idiopathic retroperitoneal fibrosis, Inflammatory aneurysm of abdominal aorta. RN Jois, K Gaffney, T Marshall, DGI Scott. Rheumatology 2004; 43:1441-6

A Pair of Buttocks. S Bawa, K Gaffney, TJ Marshall. Rheumatology 2004 ; 43:669-9

Intervertebral discitis presenting as oligoarthritis. T Marshall, K Gaffney. Ann Rheum Dis 2004; 63:634-5

Near fatal case of the dapsone hypersensitivity syndrome. KS Leslie, K Gaffney, CN Ross, S Ridley, TH Barker, J Garioch. Clinical Dermatology 2003; 28: 496-8

Rheumatoid Nodules. T Marshall, K Gaffney. BMJ 2002; 324: 858

A swollen leg unmasks longstanding SLE. SE Lane, K Gaffney, RY Ball, .M Marshall. Lupus 2001; 10: 4-8.

Ear, ear, what’s going on in Norfolk. E Clarke, K Gaffney, P Merry, D. O’Gradaigh, D.Scott. Ann Rheum Dis 1999: 58; 660.

Unusual and memorable. Periostitis and bone proliferation. D O’Gradaigh, C Blundell, T Marshall, K Gaffney, P Chapman. Ann Rheum Dis 1999: 58; 263.

Interosseous nerve entrapment syndromes complicating inflammatory arthritis. K Gaffney, V Jolliffe, P Merry. Clin Exp Rheumatol 1997; 15: 339-40.

ANCA-positive polyarthritis associated with minocycline therapy. K Gaffney, P Merry. Br J Rheumatol 1996; 35: 1327.

Amyloidosis Complicating Cystic Fibrosis. K Gaffney, D Gibbons, B Keogh, MX FitzGerald. Thorax 1993; 48: 949-50.

Eosinophilic Fasciitis: A good response with conservative treatment. K Gaffney, G Kearns, D Moraes, JF O’Dowd, EB Casey. Ir J Med Sci 1993; 162: 256-7.

Book Chapters

Spinal Pain. Hamilton L, Gaffney K. Oxford Textbook of Rheumatology 4th Edition; 87-91